99% Veterinary use Pomalidomide powder with CAS 19171-19-8
Product Name: Pomalidomide
CAS: 19171-19-8
MF: C13H11N3O4
MW: 273.24
EINECS: 805-902-5
Melting point 318.5 - 320.5°
Boiling point 582.9±45.0 °C(Predicted)
density 1.570±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥14mg/mL
pka 10.75±0.40(Predicted)
form powder
color yellow
99% Veterinary use Pomalidomide powder with CAS 19171-19-8
Uses Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM
Uses Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
Uses Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog. An inhibitor of LPS-induced TNFαrelease.
Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs.
Pomalidomide inhibits lipopolysaccharide (LPS) stimulated TNF-alpha release in human PBMC and in human whole blood with IC50 values of 13 nM and 25 nM, respectively. Pomalidomide inhibits the growth of T regulatory cells which is stimulated by IL-2 with an IC50 of ~1 μM. Treatment with Pomalidomide (6.4 nM-10 μM) increases the production of IL-2 in human peripheral blood T cells, and is slightly more potent in the CD4+ subset than in the CD8+ subset. Pomalidomide is significantly more potent than CC-5013 at elevating IL-2, IL-5, and IL-10 levels, but only slightly more potent than CC-5013 at elevating IFN-γ levels.
Pomalidomide enhances SEE and Raji cells induced AP-1 transcriptional activity in Jurkat cells in a dose-dependent manner, with a maximal enhancement of 4-fold at 1 μM. Exposure of Raji cells to various concentrations of Pomalidomide (2.5-40 μg/mL) for 48 hours leads to a significant decrease in cell proliferation and DNA synthesis. There is a reduction of ~40% compared to vehicle-treated controls.
| Package |
carton drum with two plastic bags inside |
| Net weight |
25KG/Drum |
| Storage |
Sealed in cool and dry place to avoid moisture and light |
| Shelf life |
2 years when properly stored |
| Lead time |
1~3 days after confirmation |
| Appearance |
Yellow or yellow-green powder |
| Identification |
MS |
| |
IR |
| Water |
≤1.0% |
| Residue on ignition |
≤0.1% |
| Heavy metals |
≤10 ppm |
| Related substance |
Single impurities≤0.1% |
| |
Total impurities≤1.0% |
| Residual solvents |
methanol≤0.3% |
| |
ethanol≤0.5% |
| |
ethyl acetate≤0.5% |
| |
DMSO≤0.5% |
| Assay |
≥99.0% |
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