99% CAS 28319-77-9 Choline Alfoscerate Powder Alpha GPC

• CAS No.: 28319-77-9
• Formula: C8h20no6p
• EINECS: 248-962-2
• Grade: Pharm
• Function: Other
• Certification: MSDS, FDA, GMP
• Model NO.: Choline alfoscerate
• Usage: Pharm
• Raw Material: 28319-77-9
• Transport Machine: Ordinary Goods Truck
• Appearance: White Powder
• Transport Package: Drum
• Specification: CP; USP; EP
• Trademark: Recedar
• Origin: China
• HS Code: 0000
• Production Capacity: 10t

Product Description

99% CAS 28319-77-9 Choline Alfoscerate powder Alpha GPC

 

Choline glycerophosphate
Choline alfoscerate
GPC
CAS 28319-77-9
Purity≥99%
AppearancePowder or Liquid
Product NameCholine glycerophosphate
SynonymsCholine alfoscerate
CAS28319-77-9
FormulaC8H20NO6P
Molecular Weight257.22000000000003
EINECS248-962-2

Choline alfoscerate is a nootropic reportedly effective in the treatment of age-associated memory impairment. In man, it decreased and prevented scopolamine-induced amnesia. In vitro studies suggest that choline alfoscerate acts indirectly on cholinergic transmission by elevating the synthesis of acetylcholine.

Physical and chemical properties
Glyceryl phosphorylcholine (GPC) is miscible with water, soluble in met hanol, ethanol, insoluble in chlo roform, ether, oil, etc., and has no characteristic absorption under ultraviolet-visible light. GPC content determination methods include high-performance liquid chromatography (equipped with evaporative light scattering detector or refractive index differential detector) and digestive phosphorus determination method.

Pharmacological action
Choline alfoscerate is an intermediate of phospholipid metabolism that occurs naturally in the human body. It exists in cells and throughout the human body. It is structurally composed of choline, glycerol, and phosp horic acid. It is a main preservation form of choline and is recognized Source of Choline. Because it is an endogenous substance, it has very low toxic and side effects. After absorption, choline phosphate is decomposed into choline and glycerophosphate under the action of enzymes in the body: choline participates in the biosynthesis of acetylcholine, which is a neurotrigger transmitter; glycerophosphate is the precursor of lecithin. Participate in the synthesis of lecithin. The main pharmacological effects include protecting the metabolism of choline, ensuring the synthesis of acetylcholine and lecithin in the nerve membrane, improving blood circulation; improving the cognitive and behavioral responses of patients with brain capillary nerve injuries. In this field, there is no better new drug on the market or research and development.

biological functions
Glycerophosphocholine is not only one of the main permeates of renal medullary cells, but also can change the concentration of permeable substances inside and outside the cells in parallel. This is beneficial to the health of cerebral blood vessels, especially the behavioral and emotional disorders caused by brain decline. Glycerophosphocholine has the potential to treat and prevent a variety of biochemical diseases. Researchers have found that it can change the structure of phosphate lipid compounds in neuronal membranes, and found that it has a peculiar effect of relieving body tension among the related factors that cause nerve tissue decline syndrome.

application
Glycerophosphocholine has been marketed in Italy, Poland, Greece, Chile, South Korea, Brazil, Russia and other countries. It not only provides the high levels of choline needed by brain cells and nerve cells, but also protects their cell walls. Patients with Alzheimer's disease are mainly manifested as memory and cognitive decline, and are accompanied by a variety of complications, such as inconvenience, nervous system disorders and other functional disorders. Both clinical pharmacological test results and clinical trials have confirmed that glycerophosphocholine is very helpful to the cognitive ability and memory function of the brain.
 

Package	carton drum with two plastic bags inside
Net weight	25KG/Drum
Storage	Sealed in cool and dry place to avoid moisture and light
Shelf life	2 years when properly stored
Lead time	1~3 days after confirmation

 
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Items	Specifications
Appearance	White powder, neutral odor,very highly hygroscopic.
Identification (TLC)	Conforms to the standard
Solubility (,10% w/v)	Clear
Stability	Dry and light protected storage;Stable under normal usage.
Specific rotation	-2.4° to -2.95°
Heavy metals(as Pb)	Not more than 10ppm
Sulfate	Not more than 0.02%
Chloride(Cl)	Not more than 0.02%
Phosphate lon	The color of solution should not stronger than the control solution(5ppm)
Residual Solvent(Ethanol)	Not more than 1.0%
PH value	5.5~7.0
Total impurities	Not more than 2.0%
Single impurity	Not more than 0.5%
Water content	Not more than 2.0%
Purity (HPLC)	≥99.5%