SFDA grade 99% Metadoxine powder with CAS 74536-44-0
Metadoxine
CAS Number: 74536-44-0
Molecular formula: C8H11NO3.C5H7NO3
Molecular weight: 298.293
EINECS number: 277-913-8
Pharmacological action
Metadoxine can improve liver damage caused by long-term drinking. Animal experiments show that metadoxine has the effect of anti-lipid peroxidation of liver cells and can reduce the accumulation of fat in liver cells of animals with chronic alcoholism.
SimultaneousMetadoxinetreatmentnotablyinhibitsadipogenicdifferentiationinadose-dependentmanner.Metadoxinetreatmentfromday4throughday8isrequiredforinhibitionofMDI-inducedpreadipocytedifferentiation.MetadoxinepreventsglutathionedepletionandtheincreaseinlipidperoxidationdamagecausedbyethanolandacetaldehydeinHepG2celChemicalbookls.Inhepaticstellatecells,MetadoxinepreventstheincreaseincollagenandattenuatedTNF-αsecretioncausedbyacetaldehyde.Thus,MetadoxinecouldbeusefulinpreventingthedamageproducedinearlystagesofalcoholicliverdiseaseasitpreventstheredoximbalanceofthehepatocytesandpreventsTNF-αinduction,oneoftheearliesteventsinhepaticdamage.
| Package |
carton drum with two plastic bags inside |
| Net weight |
25KG/Drum |
| Storage |
Sealed in cool and dry place to avoid moisture and light |
| Shelf life |
2 years when properly stored |
| Lead time |
1~3 days after confirmation |
| Tests |
Specifications |
| Character |
White or almost white crystalline powder; odourless; taste, bitter, sour. |
| Solubility |
Freely soluble in water and in metha nol, soluble in ethanol, insoluble in |
| |
chlorofo rm and in ether. |
| Melting range |
99-103ºC |
| Specific optical rotation |
-9.0°~ -12.5° |
|
| |
Chemistry reaction, should be positive reaction |
| Identification |
By IR absorption, to match with the working standard |
| |
Spectrophotometry match the working standard |
| pH |
3.5-4.5 |
|
| Sulfate |
No more than 0.01% |
| |
the sum of the areas of all impurity peaks in the chromatogram obtained |
| Related substance |
with the test solution is not greater than the area of the principle peak in |
| |
the chromatogram obtained with the reference solution ( 0.5%). |
| D-Pyroglutamic acid |
The areas of D-pyroglutamic acid is not greater than the area of the |
| |
principle peak in the chromatogram obtained with the reference solution 0.5% |
| Other amino acids |
Should comply |
| Vitamin B6 |
No turbidity is produced |
| Ethanol |
≤0.5% |
| Loss on drying |
≤0.5% |
| Residue on ignition |
≤0.2% |
| Iron |
≤0.001% |
| Heavy metals |
≤10ppm |
| Ars enic |
≤0.0001% |
| |
Bacterial count≤100cfu/g |
| Microbial limit |
Fungus and yeast count ≤10cfu/g |
| |
Escherichia coli should be absent |
| Assay |
≥98.0% |
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