Antihypertensive Drug API 145040-37-5 Candesartan Cilexetil

• CAS No.: 145040-37-5
• Formula: 145040-37-5
• EINECS: 145040-37-5
• Grade: Pharm
• Function: Pharm
• Certification: MSDS, FDA, GMP
• Model NO.: Candesartan cilexetil powder
• Usage: Pharm
• Raw Material: 145040-37-5
• Transport Machine: Ordinary Goods Truck
• Appearance: White Powder
• Water: Nmt 0.3%
• Ash: Nmt 0.1%
• Heavy Metals: Nmt 10ppm
• Transport Package: Drum
• Specification: 99%
• Trademark: Recedar
• Origin: China
• HS Code: 0000
• Production Capacity: 1000kg

Product Description

Antihypertensive drug API  145040-37-5 Candesartan Cilexetil

Candesartan cilexetil
CAS: 145040-37-5
MF: C33H34N6O6
MW: 610.66
Chemical Properties White Solid
Usage Ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive

Candesartan cilexetil is an organic compound with the molecular formula C33H34N6O6. This product is white flakes with sweet taste. It is quickly broken down into the active metabolite candesartan in the body. Candesartan is an angiotensin II AT receptor antagonist. It antagonizes the contraction of angiotensin II by binding to vascular smooth muscle AT receptors, thereby reducing peripheral vascular resistance. Suitable for essential hypertension.

Antihypertensive drug API  145040-37-5 Candesartan Cilexetil

 

 

Package	carton drum with two plastic bags inside
Net weight	25KG/Drum
Storage	Sealed in cool and dry place to avoid moisture and light
Shelf life	2 years when properly stored
Lead time	1~3 days after confirmation

                                           

Item		Specification
Appearance		White to off-white powder
Clarity and Color solution		Solution in chlorofor at 5% is clear and colourless
The	1.HPLC	The retention time of major peak in the chromatogram of the test solution corresponds to that of the standard solution, as obtained in the procedure for prganic impurities by HPLC
	2. IR	Similar to standard
Water		Not more than 0.30%
Residue on Ignition		Not more than 0.1%
Tin		NMT 10ppm
Azide by IC		NMT 10ppm
Melting range		160ºC~166ºC
Heavy Metals		Not more than 10 ppm
As		< 1 ppm
Particle size distribution		90% <30 µm 50% ≤10 µm
Organic impurities by HPLC		Ethyl Candesartan -NMT 0.15% Desethyl Candesartan -NMT 0.15% N^2-Ethyl Candesartan Cilexei -NMT 0.15% Any unknown impurity -NMT 0.10% Total impurities -NMT 0.60%
Assay by potentiometry		Not less than 99.0% - 101.0% on dried basis
OVI (organic volatile impurity)		Methano -NMT 0.3% Ethanol -NMT 0.5% Diet hyl ether -NMT 0.5% Aceton -NMT 0.5% Dichloromethan -NMT 0.06% Dimethylformamide -NMT 0.088%
Microbiological Contarnination/g		Total aerobic microbial count -1000 cfu Total combined moulds & yeasts-100 cfu Other specific micro organisms-Absent (E.Coli,Salmonella sp)
NEMA&NDEA		0.3ppm&0.18ppm

                              

 
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